The Harrison Guest House was built in 1942 by Genevieve Harrison. This establishment is located on the Historic West Side of Las Vegas, NV, which is a portion of Las Vegas where African Americans were segregated. It served as an African-American boarding house that provided accommodations to black travelers and entertainers during the mid-twentieth century. Some of these travelers include Nat "King" Cole, Billy Eckstine, Sammy Davis Jr. and Pearl Bailey. As in other cities across the country, African Americans who moved to Las Vegas after World War Two encountered segregation. Boarding houses like the Harrison Guest House became one of the few options available for African Americans who were new arrivals to a community or were traveling through the region. It is one of the only African-American boarding house that exists in Las Vegas. The house was advertised in the 1949 Edition of the Green Book on Page 55.